use of a compound, method for treating one or more of the following indications, congestive heart failure, angina, arrhythmias, circulatory disorders such as raynaud's phenomenon, migraine and anxiety and anxiety disorders, and, pharmaceutical composition

摘要

USE OF A COMPOUND, METHOD TO TREAT ONE OR MORE OF THE FOLLOWING INDICATIONS, CONGESTIVE HEART FAILURE, ANGINA, ARRHYTHMIAS, CIRCULATORY DISORDERS SUCH AS RAYNAUD PHENOMENON, MIGRAINE AND ANXIETY AND ANXIETY AND ANXIETY AND ANXIETY. Use of a compound of formula I, where R ~ 1 ~, R ~ 2 ~ and R ~ 3 ~ are the same or different and mean hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino group or dialkylamino; R ~ 4 ~ means hydrogen, alkyl or alkylaryl group; X means CH ~ 2 ~, oxygen atom or sulfur atom; n is 1, 2 or 3, with the proviso that when n is 1, X will not be CH ~ 2 ~ and the individual (R) and (S) enantiomers or mixtures of enantiomers and their pharmaceutically acceptable salts; wherein the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means a phenyl or naflula group, optionally substituted by an alkyloxy, halogen or nitro group; the term halogen means fluorine, chlorine, bromine or iodine, in the manufacture of a medicine for the treatment for one or more of the following indications, congestive heart failure, angina, arrhythmias, circulatory disorders, such as Raynaud's phenomenon, migraine and anxiety disorders .