Insulin analogues in which the end of the B chain is an Aminoacid residue, The residue n-terminal Aminoacid Chain of insulin is a lysine or arginine residue, the A8 Aminoacid position is occupied by a resid

摘要

The invention refers to a new insulin analogue, the basic time / action features of which are: (a) the B chain end is composed of basic amino acid residues, such as lysine or aminoamide, (b) The N-terminal amino acid residue from insulin chain A is a residue of lysine or argon, (c) the A8 position of amino acid is occupied by a tissue residue, (d) the A21 position of amino acid is occupied by a glycerin residue, (e) The negative loaded amino acid residues at A5, A15, A18, B-1, B0, B1, B2, B3 and B4 were replaced and / or added one or more times.