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Aryl and heteroaryl urea Chk1 inhibitors for use as radiosensitizers and chemosensitizers

机译：芳基和杂芳基脲Chk1抑制剂，用作放射增敏剂和化学增敏剂

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摘要

Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

机译：公开了可用于治疗与DNA复制中的DNA损伤或损伤有关的疾病和状况的芳基和杂芳基取代的脲化合物。还公开了制备化合物的方法及其作为治疗剂的用途，例如，用于治疗以DNA复制，染色体分离或细胞分裂缺陷为特征的癌症和其他疾病。

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公开/公告号DK1379510T3

专利类型
公开/公告日2011-08-29

原文格式PDF
申请/专利权人 ICOS CORPORATION;
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申请/专利号DK20020728396T
发明设计人 COOK ADAM WADE;KESICKI EDWARD A.;COWEN SCOTT DOUGLAS;BURGESS LAURENCE EDWARD;KEEGAN KATHLEEN S.;GAUDINO JOHN JOSEPH;
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申请日2002-03-01
分类号C07D241/20;A61K31/4965;A61K31/497;A61K31/498;A61K31/5377;A61K45/06;A61P35;A61P43;C07D213/30;C07D213/40;C07D213/75;C07D213/77;C07D215/34;C07D231/40;C07D239/42;C07D239/46;C07D241/12;C07D241/30;C07D241/44;C07D241/54;C07D251/22;C07D253/06;C07D253/07;C07D257/06;C07D277/48;C07D401/12;C07D401/14;C07D403/06;C07D403/12;C07D405/12;C07D409/12;C07D409/14;C07D453/02;C07D521;
国家 DK
入库时间 2022-08-21 18:06:50

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