PHARMACEUTICAL AGENT FOR PROMOTING THE FUNCTIONAL REGENERATION OF DAMAGED TISSUE

摘要

(1) a large number of bone marrow-derived cells are mobilized to grafted skin; (2) mobilized bone marrow-derived cells differentiate into any of dermal fibroblasts, adipocytes, muscle ceils, vascular endothelial cells, and epidermal keratinocytes in grafted skin, and thus mobilized bone marrow-derived cells include bone marrow-derived mesenchymal stem cells; (3) S100A8 and S100A9 released from necrotic tissues of grafted skin are responsible for mobilizing bone marrow-derived mesenchymal stem cells to the grafted skin from peripheral blood; and (4) purified S100A8 and S100A9 promote the migration of mesenchymal stem cells isolated/cultured from the bone marrow.