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FORMULATION AND METHOD OF ENHANCING STABILITY AND RE- ENDOTHELIALIZATION OF SIROLIMUS IN IN-STENT RESTENOSIS
FORMULATION AND METHOD OF ENHANCING STABILITY AND RE- ENDOTHELIALIZATION OF SIROLIMUS IN IN-STENT RESTENOSIS
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机译:即时再塑中增强西罗莫司的稳定性和再内皮化的公式和方法
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摘要
The present invention relates to a process for the preparation of controlled drug formulation and method of coating comprising sirolimus which enhances stability and re-endothelialization. The invention also relates to a coated implantable medical device, comprising: a pharmacologically active core; a base coating comprising a hydrophilic polymer with silymarin; a drug layer comprising sirolimus and at least one surface modifying agent with a biodegradable polymer surrounding the said core; optionally, a barrier layer over the drug coated core containing silymarin.
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