METHOD FOR PREDICTING DRUG TARGETS IN MICROBIAL PATHOGEN AND METHOD FOR SCREENING ANTIBACTERIAL COMPOUNDS USING METABOLITE ESSENTIALITY APPROACH

摘要

The present invention relates to a method for predicting a drug target in microorganisms, and more particularly, to a method comprising: selecting subject microorganisms; building a metabolic network model of the selected microorganisms; predicting a metabolite which is essential to cell growth by applying a metabolite essentiality method; removing currency metabolite and essential metabolite, the consuming reaction formula number of which falls short of a standard; additionally selecting the remaining essential metabolite and an enzyme which consumes essential metabolite but is not involved in a host metabolism; and accordingly, screening an efficient drug target enzyme in pathogenic microorganisms or a drug target gene encoding same.