METHOD FOR SEARCHING IDEAL PROTEIN STRUCTURES FOR INHIBITION OF TARGET MOLECULES WITH SIMULATION FROM ELECTRONIC LIBRARY

摘要

PURPOSE: A method for searching for a non-antibody protein that is specific to a target through simulation from an electronic library is provided to remarkably improve speed and to save costs. CONSTITUTION: A method for searching for a non-antibody protein that is specific to a target from an electronic library comprises: a step of performing a docking simulation using a non-antibody protein and target to select a non-antibody protein that is bound in more than a number of predetermined target residues; a step of calculating the binding energy of the non-antibody protein and target and arranging a non-antibody protein according the predetermined number; and a step of removing a non-antibody protein which has a level less than the predetermined level. The electronic library comprises a non-antibody protein forming a monomer, homodimer, or homotrimer.