A screening method of a prophylactic or therapeutic agent for diabetes using a homozygous transgenic mouse by HBx gene

摘要

The present invention relates to a screening method of anti-diabetic agent or prophylactic agent using the transformed homozygous (homozygote) mouse with HBx gene, specifically known as primary liver cancer inducer of the gene of the hepatitis B virus (Hepatitis B Virus) type B hepatitis virus X (hepatitis B virus X; HBx) since diabetes induced in the transgenic gene in homozygous mouse (mouse ^met HBx) relates to a method for screening an anti-diabetic agent or prophylactic agent using them. HBx ^met mouse of the present invention may be useful in the development of the correlation, and diabetes therapeutic agent or prophylactic agent of the above glucose metabolism and liver cancer caused by hepatitis B. ; Human hepatitis B virus X protein, diabetic animal models.