NOVEL CROSS-LINKING REAGENTS FOR PRODUCING CHITOSAN-BASED BIOCOMPATIBLE MATERIALS

摘要

FIELD: chemistry.;SUBSTANCE: articles based on biologically active polymer materials can be used in surgery when treating wounds and as materials for temporary replacement of body tissue, in biotechnology for obtaining matrices for growing cell cultures, in pharmaceuticals as carriers of enzymes and other biologically active compounds. The cross-linking reagents are 2,4-derivatives of 3-oxa glutaric dialdehyde (2,2'-oxydiacetaldehyde). These compounds can be obtained via periodate oxidation of monosaccharides, nucleosides and nucleotides.;EFFECT: low toxicity and biocompatibility of chitosan-based materials is achieved by using cross-linking reagents.;2 dwg, 12 ex