IMIDAZO1,2,-aPYRIDINE DERIVATIVES TO BE USED AS PEPTIDE DEFORMYLASE (PDF) INHIBITORS

摘要

FIELD: medicine.;SUBSTANCE: invention refers to a compound of formula (I): in which the radicals R¹, R², R³ and R⁴ independently represent hydrogen atom, halogen atom, hydroxy group, amino group, nitro group, an alkyl, alkenyl, cycloalkyl or aralkyl radical. And all these radicals can to be optionally substituted by haloalkyl or hydroxyalkyl, or radicals R² and R³ in combination can represent a part of an aryl rings; R⁵ represents hydrogen atom, halogen atom, hydroxy group or thiol group, an alkyl, alkenyl, alkinyl, aryl, cycloalkyl, aralkyl radical or a 5-merous heteroaromatic ring containing 1, 2 heteroatoms selected from nitrogen and oxygen; the radicals R⁶ and R⁷ independently represent hydrogen atom, an alkyl or aryl radical; and X represents a group of formula where represents a bond or CH₂, V represents O, W represents NH, a Y represents OH, or to its pharmaceutically acceptable salts, and besides to pharmaceutical composition based on said compound showing an inhibitory action on peptide deformylase (PDF).;EFFECT: new compounds which attract a great interest as new antibiotics are produced and described.;11 cl, 1 tbl