MODIFIED ADENYLATE CYCLASE BORDETELLA CONTAINING CD11b/CD18 INTERACTION DOMAIN OR CD11B/CD18 INTERACTION DOMAIN DEFICIENT, AND ITS APPLICATION

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: group of inventions refers to medicine, namely to infectious diseases, and can be used for treating whooping cough and/or for Bordetella infection protection. Polypeptide under the invention represents a fragment of adenylate cyclase Bordetella containing CD11b/CD18 interaction domain from an amino acid sequence extended from position 1166 to position 1281 SEQ ID NO:1. Said invention also concerns the specific fragments of adenylate cyclase Bordetella containing CD11b/CD18 interaction domain, and to their application, particularly for targeting of molecules of interest to CD11b expressing cells.;EFFECT: use of the inventions allows extending the range of products for treatment and prevention of the Bordetella infection.;26 cl, 9 dwg