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New substituted ferrocene derivative useful as ligands in catalysis of carbon-carbon and carbon-heteroatom linking reactions, in hydrogenation reactions, preferably Suzuki reaction and for preparing multi ortho-substituted biaryls
New substituted ferrocene derivative useful as ligands in catalysis of carbon-carbon and carbon-heteroatom linking reactions, in hydrogenation reactions, preferably Suzuki reaction and for preparing multi ortho-substituted biaryls
Substituted ferrocene derivative (I) is new. Substituted ferrocene derivative of formula (I) is new. A : single bond or R 6; R 1 : (cyclo)alkyl (optionally branched), aryl (both optionally substituted by alkyl (optionally branched), aryl, halo, NH 2, thioether, nitrile or carboxylic acid) or H; either R 2-R 5 : alkyl (optionally branched), aryl, cycloalkyl, alkoxy, aryloxy, N(alkyl) 2, N(aryl) 2(all optionally substituted by alkyl (optionally branched), aryl, halo, ether, NH 2, thioether, nitrile or carboxylic acid) or halo; or R2+R3 or R4+R5 : phosphetane compound of formula (Ia) (optionally saturated and optionally branched); q : 1 or 2; R 7, R 8 : alkyl (optionally branched), preferably CH 3, CH 2CH 3, CH(CH 3) 2, C(CH 3) 3or cycloalkyl; R 6 : alkanediyl, benzenediyl, 2,2'-substituted 1,1'-binaphthyl, 1,8-naphthylene, 2,2'-substituted 1,1'-binaphthadiyl, 1,8-naphthadiyl or ferrocenyl derivative; T : alkyl, Si(alkyl) 3,Si(alkyl) 2(aryl), Si(alkyl)(aryl) 2, Si(aryl) 3(where alkyl and aryl are optionally substituted by alkyl (optionally branched), halo, ether, amine, thioether, nitrile or carboxylic acid); either n : 0-2; and o : 0-5; or n+o : = 5. Independent claims are also included for: (1) preparing (I); (2) a metal compound of formula (ML kX m); and (3) a kit comprising at least one of the compounds of group 8-10 of the periodic table of elements (according to IUPAC Nomenclature of Inorganic Chemistry 1989), preferably nickel, palladium (both preferred), rhodium, iridium, ruthenium or cobalt. M : transition metal of group 8-10 of the periodic table of elements (according to IUPAC Nomenclature of Inorganic Chemistry 1989), preferably nickel, palladium (both preferred), rhodium, iridium, ruthenium or coba L : (I); k : 1-3; X : chloride, bromide, iodide, acetate, acetylacetonate, nitrate, H 2CSi(CH 3) 3or H 2CSi(CH 3) 2(C 6H 5); and m : 0-4. [Image].
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机译：取代的二茂铁衍生物（I）是新的。式（I）的取代的二茂铁衍生物是新的。 A：单键或R 6>; R 1>：（环）烷基（任选地支链），芳基（均任选地被烷基（任选地支链）取代，芳基，卤素，NH 2，硫醚，腈或羧酸）或H; R 2> -R 5>之一：烷基（可选地分支），芳基，环烷基，烷氧基，芳氧基，N（烷基）2，N（芳基）2（全部可选地被烷基（可选地分支），芳基，卤素，醚取代，NH 2，硫醚，腈或羧酸）或卤素;或R 2 + R 3或R 4 + R 5：式（Ia）的磷杂环丁烷化合物（任选地饱和和任选地分支的）; q：1或2; R 7＞，R 8＞：烷基（任选地分支的），优选CH 3，CH 2CH 3，CH（CH 3）2，C（CH 3）3或环烷基; R 6>：烷二基，苯二基，2，2′-取代的1，1′-联萘基，1，8-萘，2，2′-取代的1，1′-联萘二基，1，8-萘二基或二茂铁基衍生物; T：烷基，Si（烷基）3，Si（烷基）2（芳基），Si（烷基）（芳基）2，Si（芳基）3（其中烷基和芳基任选地被烷基（任选地分支的）取代，卤素，醚，胺，硫醚，腈或羧酸）; n：0-2;或者o：0-5; n。或n + o：=5。还包括以下方面的独立声明：（1）准备（I）; （2）式（ML kX m）的金属化合物; （3）试剂盒，其包含元素周期表中第8-10组的化合物中的至少一种（根据IUPAC无机化学名称，1989年），优选镍，钯（均优选），铑，铱，钌或钴。 M：元素周期表第8-10族的过渡金属（根据IUPAC命名法，无机化学1989），优选镍，钯（均优选），铑，铱，钌或钴; L：（I）; k：1-3; X：氯化物，溴化物，碘化物，乙酸盐，乙酰丙酮化物，硝酸盐，H 2CSi（CH 3）3或H 2CSi（CH 3）2（C 6H 5）;和m：0-4。 [图片]。
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