Process for the preparation of a drug delivery system based on polyelectrolyte complexes

摘要

The invention relates to the fields of polymer chemistry, pharmacy and medicine and relates to a method which releases pharmaceutical substances in the vicinity of the implant, for example as a component of implants. The object of the present invention is to provide a method which generates a drug delivery system in a simple and reproducible manner, which releases drugs in a targeted and controllable manner with a delay. The object is achieved by a method in which polyanions and polycations are mixed in a non-stoichiometric ratio, based on the charged monomer units, in a liquid, a drug being added either before, during or after the mixing of the polyelectrolytes, or a charge-carrying drug and an oppositely charged polyelectrolyte is mixed, and after the mixing, the resulting polyelectrolyte complex is applied to the surface or the surface area of a medical agent or is positioned directly at the location where the drug is to be released.