PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASE OR REGRESSIVE ENCEPHALOPATHY, OR FOR IMPROVING MEMORY DISORDER, CONTAINING ILEX LATIFOLIA EXTRACT AS ACTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To provide a therapeutic composition for preventing or treating ischemic disease or regressive encephalopathy, containing an Ilex latifolia extract as an active ingredient.SOLUTION: To put it concretely, it is confirmed that the Ilex latifolia extract extracted by using water, an alcohol or a mixture thereof as a solvent suppresses cerebral infarction and cerebral edema in a cerebral infarction-induced rat, suppresses memory disorder in a mouse having neurotoxicity induced by amyloid -protein [A(25-35)] administered thereto, and suppresses in a dose-dependent way, cell death of cerebral cortex neurocyte guided by oxidation stress induced by hydrogen peroxide, glutamic acid which is an excitatory amino acid, A(25-35) inducing neurotoxicity, and hypoxia. Consequently, the Ilex latifolia extract is utilized usefully as an active ingredient for a therapeutic composition for preventing or treating ischemic disease or regressive encephalopathy, or for functional food for health.