Method for antagonizing activin and TGF-b signaling by Cripto

摘要

Cripto, a developmental oncoprotein, antagonizes activin and TGF-² signaling by forming a complex with activin and TGF-² and their type II receptors. This complex precludes the formation of a functional activin/TGF-²€¢type II€¢type I complex, thereby blocking the signaling of activin and TGF-². Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-² complex may enhance antiproliferative effects of activin and TGF-².