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Methods of preventing virus: cell fusion by inhibiting the function of the fusion initiation region of RNA viruses with class I membrane fusion-inducing envelope proteins
Methods of preventing virus: cell fusion by inhibiting the function of the fusion initiation region of RNA viruses with class I membrane fusion-inducing envelope proteins
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机译:预防病毒的方法:通过抑制诱导I类膜融合的包膜蛋白抑制RNA病毒融合起始区功能来进行细胞融合
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摘要
The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus (thereby preventing delivery of the viral genome into the cell cytoplasm, a step required for viral infection). The present invention particularly relates to the families of RNA viruses, including the arenaviruses, coronaviruses, filoviruses, orthomyxoviruses, paramyxoviruses, and retroviruses, having Class I membrane fusion proteins as the fusion proteins that mediate this fusion process. The present invention provides for a method of identifying a conserved motif or domain called the fusion initiation region (FIR) in these viruses. The present invention further provides for methods of preventing infection by such viruses, by interfering with their FIR. The present invention further provides for methods of treatment and prophylaxis of diseases induced by such viruses.
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