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Method for determining active ingredient (in vitro dePEGylation) in prodrug PEG protein conjugates with releasable PEG reagents
Method for determining active ingredient (in vitro dePEGylation) in prodrug PEG protein conjugates with releasable PEG reagents
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机译:用可释放的PEG试剂测定前药PEG蛋白缀合物中活性成分的方法(体外脱PEG化)
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摘要
The present invention relates to an in vitro method of releasing a reversibly-linked water-soluble polymer from a protein modified by the water-soluble polymer comprising the step of incubating the protein under conditions effective to release the water-soluble polymer, wherein the conditions comprise increasing free amine concentration of a buffer comprising the protein to a free amine concentration effective to release the water-soluble polymer.
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