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PROPHYLACTIC OR THERAPEUTIC AGENT FOR RETINAL DISEASE AND METHOD FOR PROPHYLAXIS OR THERAPY OF RETINAL DISEASE USING JNK (C-JUN AMINO-TERMINAL KINASE) - INHIBITORY PEPTIDE, AND USE OF THE PEPTIDE
PROPHYLACTIC OR THERAPEUTIC AGENT FOR RETINAL DISEASE AND METHOD FOR PROPHYLAXIS OR THERAPY OF RETINAL DISEASE USING JNK (C-JUN AMINO-TERMINAL KINASE) - INHIBITORY PEPTIDE, AND USE OF THE PEPTIDE
Intravitreal administration of a JNK-inhibitory peptide less than 150 amino acids in length, containing at least one D-amino acid, and having (a) a JNK-inhibitory sequence of at least any of SEQ ID NO: 1 and SEQ ID NO: 2, and (b) a transport sequence of at least any of SEQ ID NO: 3 and SEQ ID NO: 4 suppressed spermidine-induced retinal pigment epithelial damage, tunicamycin-induced photoreceptor cell damage, and laser-induced choroidal neovascularization. Thus, the JNK-inhibitory peptide of the present invention is useful for prophylaxis or therapy of a retinal disease. By the use of this JNK-inhibitory peptide, a drug and a method are provided which are capable of preventing or treating a retinal disease even by topical administration to the eye, and use of the JKN-inhibitory peptide for manufacturing the drug is also provided.
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机译:玻璃体内施用长度小于150个氨基酸,含有至少一个D-氨基酸且具有(a)SEQ ID NO:1和SEQ ID NO:中至少一个的JNK抑制序列的JNK抑制肽参见图2,并且(b)至少SEQ ID NO:3和SEQ ID NO:4中任一个的转运序列抑制了亚精胺诱导的视网膜色素上皮损伤,衣霉素诱导的感光细胞损伤和激光诱导的脉络膜新血管形成。因此,本发明的JNK抑制肽可用于预防或治疗视网膜疾病。通过使用这种JNK抑制肽,提供了一种即使通过局部施用于眼睛也能够预防或治疗视网膜疾病的药物和方法,并且还提供了该JKN抑制肽在制备该药物中的用途。 。
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