MICROFLUIDIC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES WITH PROBES HAVING LONG FLUORESCENCE LIFETIME FLUOROPHORES

摘要

A microfluidic device for detecting a target nucleic acid sequence, the microfluidic device having a probe for hybridization with the target nucleic acid sequence to form a probe-target hybrid, the probe having a fluorophore for generating fluorescence emissions in response to an excitation light, a photodiode for detecting the fluorescence emissions, and, CMOS circuitry activating the photodiode, wherein, the fluorophore has a fluorescence lifetime longer than 100 nanoseconds.