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Anti-peptide antibodies that cross react with protective antigen of Bacillus anthracis and uses thereof
Anti-peptide antibodies that cross react with protective antigen of Bacillus anthracis and uses thereof
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机译:与炭疽杆菌保护抗原交叉反应的抗肽抗体及其用途
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摘要
The present invention provides a purified peptide comprising at least one of the sequences LKQKSSNSRKKRSTS (SEQ ID NO:1), or VKNKRTFLSPWISNI (SEQ ID NO:2) as well as a vaccine, a method to protect or treat an animal from anthrax toxin, a method of making a vaccine and the use of the peptide. The present invention also provides a monoclonal antibody that specifically binds to a peptide sequence comprising at least one of the following peptide sequences: LKQKSSNSRKKRSTS (SEQ ID NO:1), or VKNKRTFLSPWISNI (SEQ ID NO:2) as well as a method to protect or treat an animal from anthrax toxin, a method of making a vaccine, a pharmaceutical composition, a method of making a pharmaceutical composition, and the use of the monoclonal antibody.
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机译:本发明提供了包含至少一个序列LKQKSSNSRKKRSTS(SEQ ID NO:1)或VKNKRTFLSPWISNI(SEQ ID NO:2)的纯化的肽以及疫苗,一种保护或治疗动物免受炭疽毒素侵害的方法,制备疫苗的方法和该肽的用途。本发明还提供了与包含以下肽序列中的至少一个的肽序列特异性结合的单克隆抗体,以及一种保护方法,该LKQKSSNSRKKRSTS(SEQ ID NO:1)或VKNKRTFLSPWISNI(SEQ ID NO:2)或从炭疽毒素中治疗动物,制备疫苗的方法,药物组合物,制备药物组合物的方法以及单克隆抗体的用途。
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