Method for quickly normalize Vitamin B12 levels in patients with Vitamin B12 deficiency and an average level of vitamin B12 below 350 pg / ml

摘要

This paper introduces the methods of standardization of vitamin B12 in patients with low vitamin B12 content and the methods of standardization of internal variability in the treatment of these patients. Methods to reduce the levels of MMA (methylmalonic acid) and / or isomers and effective drug synthesis to achieve these changes are also described. Requirement 1: a method for rapidly standardizing vitamin B12 levels in patients with vitamin B12 deficiency and vitamin B12 levels below 350 pg / ml, including administration for at least 15 days per day,One or more oral contraceptives containing an N - [8 - (2-hydroxybenzoic acid) amino group or a medically acceptable acrylic acid (II) vitamin B12, and an optional trefoil, In this substance, the daily total amount of propylene - [8 - (2-hydroxybenzoic acid) or medically acceptable acrylate is 50-250 mg, and the daily total dose of vitamin B12 is 0.5-2 mg,Normalize vitamin B12 levels within 15 days. ILO Convention No. 7: a method of reducing the content of methylmalonic acid in a patient with a high content of MMA, in which the content of MMA is at least 150 ml / L, Methods containing one or more oral doses, including (I) n [8 - (2-hydroxybenzoic acid) amino or containing a pharmaceutically acceptable propene (II) vitamin B12, or optional (III) folic acid,The daily total amount of oxyacetic acid (n - [8 - (2-hydroxybenzoic acid) or acceptable medicament salt is 50-250 mg, the daily total dose of vitamin B12 is 0.5-2 mg, and the patient's MMA level is standardized within 15 days. ILO Convention No. 11: a way to reduce the level of homosexuality of high standard homosexual patients, in which the level of homosexuality of patients is at least 13 ml / L, Methods containing one or more oral doses, including (I) octa (n - [2-hydroxybenzoic acid) amino group or a pharmaceutically acceptable salt,(II) vitamin B12, as well as selective (III) folic acid, in which n - [8 - (2-hydroxybenzoic acid) amino] or salts with drug acceptability have a total daily dose of 50-250 mg and a total daily dose of vitamin B12 of 0.5-2 mg, There, patients' homosexuality levels normalized within 15 days. ILO Convention No. 16: an oral dosage form consisting of: (a) vitamin B12 (b) n - [8 - (2-hydroxybenzoic acid) amino or a medically acceptable acrylic acid, and (c) folic acid. ILO Convention No. 17: Convention No. 16.Dosage forms include 50-250 mg of N - [8 - (2-hydroxybenzoic acid) amino or a pharmaceutically acceptable salt, and 0.5-2 mg of vitamin B12. ILO Convention No. 18: an oral dosage form consisting of: (a) proton pump inhibitors; (b) vitamin B1; (c) n - [8 - (2-hydroxybenzoic acid) sodium amino acid; and (d) folic acid. ILO Convention No. 20: an oral contraceptive consisting of: (a) formaldehyde; (b) vitamin B12 (c) n - [8 - (2-hydroxybenzoic acid) sodium amino acid and (d) acetic acid.