The method assisted by computer generating a compound that inhibits the activity of glutamine synthetase, method of generating a test compound, method of screening for a compound protease inhibitor, in vitro method to inhibit growth of bacteria and the use of a serine protease inhibitor

摘要

The method assisted by computer generating a compound that inhibits the activity of glutamine synthetase, method of generating a test compound, method of screening for a compound protease inhibitor, in vitro method to inhibit growth of bacteria and the use of a serine protease inhibitor. Methods of screening and model compounds as inhibitors of glutamine synthetase are provided here.Compounds, for example, inhibitors of serine protease, and compositions comprising the same, which are useful for the treatment, prevention, and / or the improvement of bacterial infections, including Mycobactenum tuberculosis, are also provided.