recombinant non-naturally occurring recombinant nucleic acid molecule, recombinant cell, immunogenic composition, antibody, method for detecting the presence of campylobacter pilus pilus protein and method for detecting an antibody that specifically binds to a campylobacter jejuni pilus protein

摘要

RECOMBINANT NUCLEIC ACID MOLECULE THAT DOESN'T NATURALLY OCCUR, RECOMBINANT CELL, IMMUNOGENIC COMPOSITION, ANTIBODY, METHOD TO DETECT THE PRESENCE OF CAMPYLOBACTER PILUS PROTEIN AND AHMATIC DETECTOR TOOTHATIC TO DETECT A DETECTIVE DETECTOR The present invention provides coding and amino acid sequences for a pilus protein from Campylobacter jejuni (and other species as well). This protein, when administered to a human or animal, gives rise to the expression of an immune response to CampyIobacter jejuni, with the result that colonization and / or infection by that organism is reduced. Recombinant protein or biofilm material comprising the pilus protein is formulated in immunogenic compositions, especially for administration via the mucosa. Thus, the present invention provides methods for improving the microbial quality of food products, including poultry, eggs, meat and dairy products, and indirectly of foods of plant origin that may come in contact with agricultural waste, from fertilization or from irrigation water.