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Method for identifying persons with increased genetic risk of decease after myocardial infarction

机译:识别心肌梗死后遗传风险增加的人的方法

摘要

In the present invention, there is described a method for identifying persons with increased genetic risk of decease due to cardiovascular complications within 6 months from the moment of occurrence of acute myocardial infarction wherein the method is characterized in that there is determined in a biological sample taken from a patient body the intensity of gene expression and genetic loci ADORA3, (M97723), ERLIN1, CLYBL, TCEA3, (BC070337), HSD17B8, FLT3, AXIN2 and (CR596519). Subsequently logarithmic value of the expression intensity at the base of 2 is then compared with a reference value of the expression intensity, whereby a deviation from the reference value equal to at least a minimum deviation of all indicated genes and genetic loci represents an increased risk.
机译:在本发明中,描述了一种在急性心肌梗塞发生后的6个月内鉴定出因心血管并发症而具有增加的遗传风险的人的方法,其中该方法的特征在于确定所采集的生物学样品。来自患者身体的基因表达强度和基因位点ADORA3(M97723),ERLIN1,CLYBL,TCEA3(BC070337),HSD17B8,FLT3,AXIN2和(CR596519)。随后,将表达强度的以2为底的对数值与表达强度的参考值进行比较,由此与参考值的偏差至少等于所有所示基因和遗传基因座的最小偏差表示增加的风险。

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