APPLICATION OF PRECONDENTS OF SEXUAL STEROID HORMONES IN COMBINATION WITH A SELECTIVE MODULATOR OF ESTROGEN RECEPTORS FOR THE TREATMENT OF DISEASES AND CONDITIONS IN POSTMEN-PULSE WOMEN

摘要

The use and pharmaceutical compositions are described for treating and / or reducing the likelihood of acquired symptoms or diseases due to menopause in postmenopausal women, in particular osteoporosis, vaginal atrophy and dryness, hypogonadism, low libido, skin atrophy, collagenosis, urinary incontinence, breast cancer, endometrial cancer , ovarian cancer and cancer of the uterus, hot flashes, loss of muscle mass, insulin resistance, fatigue, loss of energy, aging, physical symptoms of menopause, in sensitive warm-blooded from, including people, including the introduction of a precursor of sex steroid hormones. The invention provides new methods for administering and dosing dehydroepiandrosterone (DHEA) to utilize the positive androgenic effects in the vaginal layers of lamina propia (lamina propria) and / or muscularis (muscularis lamina) without causing unwanted systemic estrogenic effects to avoid the risk of breast cancer glands and cancer of the uterus.