METHOD FOR MAKING 3A-HYDROXYamp;NBSP; 3ß- METHYL-5A-PREGNAN-20-ONE (GANAXOLONE)

摘要

METHOD FOR MAKING 3α-HYDROXY, 3β-METHYL-5α-PREGNAN-20-ONE (GANAXOLONE) Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α- pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula. Figure 1 is the representative figure.