METHOD AND APPARATUS RELATING TO FLUORESCENCE IMAGING AND POINT-WISE SPECTROSCOPY FOR IN VIVO TISSUE MEASUREMENTS AT ENDOSCOPY

摘要

Method and Apparatus Relating to Fluorescence imaging and point-wise Spectroscopy for in vivo Tissue Measurements at EndoscopyAbstract. We report on the development of an nifegated point-wise spectroscopy and autofluorescence (AF) endoscopic imaging technique for real-time in vivo tissue measurements at endoscopy We implement a unique optical design to realize real-bine AF unaging and AF/ ,or e (DE spectroscopy ineasuretnents from a sinall area (100[err]m in diameter) of fissue of interest on the AF image- We denionstratr that, both the AF iniage and the point-wise i AFIDR spectra can he sinniltmeously acquired from the oral cavity in -viva within 01 second, and significant dianges AF imaging and point-wise AF spectroscopy can be observed in cancerous colonic and head and neck tissues- This work demonstrates the potential. of applying ' the integrated spectroscopytechnique developed to facilitate in viva tissue diagnosis and charicterizatton at endowmpy Figure 1.