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SENSITIZATION OF CANCER CELLS FOR THERAPY USING SINA TARGET GENES FROM CHROMOSOME REGIONS 1P AND 19Q
SENSITIZATION OF CANCER CELLS FOR THERAPY USING SINA TARGET GENES FROM CHROMOSOME REGIONS 1P AND 19Q
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机译:使用来自1P和19Q染色体区域的SINA靶基因来敏化用于治疗的癌细胞
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摘要
The invention relates to the identification of genes involved in resistance of cancer cells to therapy, to short nucleic acid molecules which inhibit the expression of these genes by RNA interference and to their use as adjuvant in cancer therapy, to sensitize cancer cells to conventional anticancer agents ; said short nucleic acid molecules are double-stranded short interfering nucleic acid molecules comprising a sense and an antisense region, wherein the sense region comprises a nucleotide sequence that is selected from the group consisting of: the sequences SEQ ID NO: 15, 11, 13, 14, 30, 31, 38, 46, 64 and 70 and the sequences having at least 70 % identity, preferably at least 80 % identity, more preferably at least 90 % identity with said sequences, and the antisense region comprises a nucleotide sequence that is complementary to the sense region.
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机译:本发明涉及与癌细胞抗性有关的基因的鉴定,通过RNA干扰抑制这些基因表达的短核酸分子及其在癌症治疗中作为佐剂的用途,使癌细胞对常规抗癌药敏感。 ;所述短核酸分子是包含有义和反义区的双链短干扰核酸分子,其中所述有义区包含选自以下的核苷酸序列:序列SEQ ID NO:15、11、13 ,14、30、31、38、46、64和70,以及与所述序列具有至少70%同一性,优选至少80%同一性,更优选至少90%同一性的序列,并且反义区包含核苷酸序列与感官区域互补。
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