Using a combination of n-acetyl-cysteine ​​and lipoic acid for the preparation of a medicament useful for treating a disease with axonal damage and concomitant drug oxidative damage.

摘要

Use of a combination of N-acetylcysteine ​​and lipoic acid for the preparation of a medicament useful for treating a disease with axonal loss and concomitant drug oxidative damage.; The present invention is a combination of N-acetylcysteine ​​(NAC) and alpha-lipoic acid (LA), or pharmaceutically acceptable salts thereof, for the prevention and / or treatment of a disease with axonal damage and concomitant oxidative injury in a mammal in particular of X-linked adrenoleukodystrophy (X-ALD). The murine model of X-ALD shows a neurological phenotype late disease locomotor deficits and axonal degeneration as predominant and characteristic of the disease pathologies. The inventors have found that treatment of murine models of X-ALD with two active substances gets reverse oxidative stress and injury from protein spinal cord as target organ of the disease on the one hand, but also achieves prevent and reverse axonal degeneration and correct the locomotor deficits presented by the murine model of the disease, ie, their clinical symptoms.