Medicinal composition comprising an HMG-CoA reductase inhibitor and an amino alcohol derivative as an immunosuppressant

摘要

A medicinal composition comprising at least one agent selected from the group consisting of HMG-CoA reductase inhibitors and at least one compound selected from the group consisting of amino alcohol derivatives having the general formula (I): [wherein R1 and R2 are the same or different and each represents a hydrogen atom or a lower alkyl group, R3 represents a lower alkyl group or a hydroxymethyl group, R4 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group or an atom of halogen, R5 represents a hydrogen atom, a halogen atom, a cyclohexyl group, a phenyl group or a phenyl group substituted with 1 to 3 substituents selected from the Group of substituents a, X represents a methylated nitrogen atom, Y represents a single bond, an oxygen atom, a sulfur atom or a carbonyl group, Z represents a single bond, a C1-C8 alkylene group or a substituted C1-C8 alkylene group gone from 2 to 8 fluorine atoms, n represents an integer of 2 or 3, Group of substituents a represents the group consisting of a halogen atom, a cyano group, a lower alkyl group, a lower cycloalkyl group, a lower alkoxy group, a trifluoromethyl group, a phenyl group and a benzyloxy group, the "lower alkyl group" is a methyl, ethyl, propyl, isopropyl, butyl, isobutyl, s-butyl, t-butyl, pentyl or hexyl group, the "lower alkoxy group" is a methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, s-butoxy, t-butoxy, pentoxy or hexyloxy group, and the "lower cycloalkyl group" is a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group] , pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof.