Variants of Hepatitis B virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof

摘要

The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both and . More in particular, reverse transcriptase mutant rt 1233 V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti- viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described. Finally, the use of a farmaceutical composition to cure a subject suffering from a HBV infection, which HBV is resistant to lamuvidine and/or adefovir has been provided, which farmaceutical composition comprises the nucleoside analogue tenofovir.