Analysis method for determining a functional parameter of an organ using preferably an aqueous 13C methacetin solution

摘要

The invention relates to an analysis method for determining a functional parameterof an organ of a human or animal individual by measuring the COcontent in the air exhaled by the individual to which a substrate has been administeredthe reaction of which in the body of the individual enriches the air exhaled bythe individual with CO. The method is characterizedby using a measuring device, the maximum reaction rate of the substrate in thebody of the individual being determined via a change of the measured COcontent in the air exhaled by the individual using zero-order enzyme kinetics.The invention also relates to an aqueous methacetin solution for use in said analysismethod, the pH of the solution being greater 7.0. The invention also relates toa face mask (1) for use in the inventive method for separating the exhaled air fromthe air inhaled by an individual. Said face mask comprises a face mask body (2)and an air cushion (3) encircling the face mask body. Said air cushion is filledwith a gas and establishes a substantially gas-tight contact between the faceof the individual and the face mask (1) placed on the face of the individual so thatthe air required by the individual for breathing and the air exhaled by the individualhas to flow essentially completely through the face mask (1). At least one exhalationvalve (5) and at least one inhalation valve (4) are integrated into the face maskand allow a flow of inhaled and exhaled air through the face mask. The inventionfinally relates to a diagnostic method for determining the functional parametersof an organ of a human or animal individual.