ORAL PHARMACEUTICAL COMPOSITION CONTAINING INCLUSION OF EDARAVONE AND CYCLODEXTRIN AND PREPARATION METHOD THEREOF

摘要

An oral pharmaceutical composition containing inclusion of edaravone and cyclodextrin and the preparation method thereof are disclosed. The weight ratio of edaravone to cyclodextrin is 1:6-100. Cyclodextrin is selected fromβ- cyclodextrin or the mixture of cyclodextrins containing β- cyclodextrin. The preparation method comprises the following steps: mixing β- cyclodextrin or the mixture of cyclodextrins containing β- cyclodextrin with 1-5 times of water in weight, adding edaravone or its solution in organic solvent into the cyclodextrin solution, grinding or stirring, and then evaporating water at the temperature no higher than 60℃, drying by decompression to obtain white powder inclusion.