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DOUBLE-STRANDED NUCLEIC ACID MOLECULE, CANCER CELL PROLIFERATION INHIBITOR AND PHARMACEUTICAL AGENT SUITABLE FOR PREVENTION OR TREATMENT OF UTERINE CANCER, BREAST CANCER AND BLADDER CANCER
DOUBLE-STRANDED NUCLEIC ACID MOLECULE, CANCER CELL PROLIFERATION INHIBITOR AND PHARMACEUTICAL AGENT SUITABLE FOR PREVENTION OR TREATMENT OF UTERINE CANCER, BREAST CANCER AND BLADDER CANCER
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机译:双链核酸分子,癌细胞增殖抑制剂和药物制剂适用于预防或治疗子宫癌,乳腺癌和膀胱癌
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摘要
The present invention aims to provide a double-stranded nucleic acid molecule (e.g., siRNA) which can effectively inhibit the proliferation of uterine, breast and bladder cancer cells by suppressing the expression of at least one target gene of COX7RP and Efp genes (estrogen-responsive genes); a cancer cell proliferation inhibitor; and a pharmaceutical agent. Specifically, the present invention relates to a double-stranded nucleic acid molecule for suppressing the expression of at least one of COX7RP and Efp genes which includes (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 38 and (b) an antisense strand which includes a nucleotide sequence complementary to that of the sense strand specified in (a); a cancer cell proliferation inhibitor with the double-stranded nucleic acid molecule and against at least one of uterine, breast and bladder cancer cells; and a pharmaceutical agent with the cancer cell proliferation inhibitor and against at least one of uterine, breast and bladder cancers.
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机译:本发明旨在提供一种双链核酸分子(例如,siRNA),该双链核酸分子可以通过抑制COX7RP和Efp基因的至少一个靶基因的表达来有效抑制子宫,乳腺癌和膀胱癌细胞的增殖。响应基因);癌细胞增殖抑制剂;和药剂。具体地,本发明涉及用于抑制COX7RP和Efp基因中的至少一个的表达的双链核酸分子,其包括(a)有义链,所述有义链包括对应于由以下任一项指示的靶序列的核苷酸序列。 SEQ ID Nos:1至38和(b)反义链,其包含与(a)中指定的有义链的核苷酸序列互补的核苷酸序列;一种具有双链核酸分子并针对子宫,乳腺癌和膀胱癌细胞中的至少一种的癌细胞增殖抑制剂;以及具有癌细胞增殖抑制剂并且针对子宫癌,乳腺癌和膀胱癌中的至少一种的药剂。
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