METHOD AND ASSAY FOR PREDICTING LONG-TERM EFFICACY OF TAMOXIFEN TREATMENT IN ESTROGEN RECEPTOR-POSITIVE BREAST CANCER PATIENTS

摘要

Methods for prediction of resistance to anti-estrogen therapy in breast cancer patients with ER-positive breast tumor. The method concerns the use of quantitative measurements of the expression level of BCL2 and CDKN1A to determine i) the likelihood of a beneficial response to anti-estrogen therapeutic agents, such as tamoxifen; and ii) the potential magnitude of beneficial response to chemotherapy.