APPARATUS AND METHODS FOR IN VIVO TISSUE CHARACTERIZATION BY RAMAN SPECTROSCOPY

摘要

A micro-Raman spectrometer system for use in differentiating tumor lesions from normal skin detects specific characteristics of Raman spectra indicative of cancer. A peak at 899 cm1 and a higher intensity region in the 1325 cm1 to 1330 cm1 range indicate the presence of tumors. The spectrometer system may be applied for skin cancer detection and for mapping the margins of lesions. Cancer detection methods as described herein have achieved diagnostic sensitivity of 95.8% and specificity of 93.8%.