PEPTIDE FRAGMENTATION AS AN APPROACH IN MODELING OF AN ACTIVE PEPTIDE AND DESIGNING A COMPETITIVE INHIBITORY PEPTIDE FOR HMG-COA REDUCTASE

摘要

PURPOSE: A peptide which suppresses HMG-CoA reductase is provided to suppress cholesterol synthesis and to treat cardiovascular diseases. CONSTITUTION: A peptide which suppresses HMG-CoA reductase contains a sequence selected from sequence numbers 1-5. A cholesterol synthesis inhibitor contains the peptide. The cholesterol synthesis inhibitor is used for treating cardiovascular diseases.