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Method for Screening of ALK gene rearrangement and diagnosis of cancer using the same

机译:筛选ALK基因重排的方法和使用该方法的癌症诊断方法

摘要

It is related to a kind of Method for cancer diagnostics by the ALK a-proteins LK gene rearrangements of the present invention as caused by genetic potential of ALK ALK antibody responses, including detection method and they is determined by overexpression. The ALK gene rearrangements detected according to the present invention by method provide a shortcomings that specific ALK antibody responses are to supplement common detection methods, detection method is that a high cost takes a long time fishing contamination pattern analysis based on agreement and ALK, ALK protein overexpressions provide a kind of method by effectively analytical model, can be for detecting ALK gene rearrangements effectively pangareum dispensing subjects to rapidly and accurately whether main ALK mortifiers, the range of extension treatment (therapy), can be using the molecular target with effect.
机译:本发明涉及由ALK ALK抗体应答的遗传潜能引起的通过本发明的ALKα-蛋白LK基因重排进行癌症诊断的方法,包括检测方法,通过过表达来确定。根据本发明通过方法检测的ALK基因重排提供了缺点,即特定的ALK抗体应答将补充常见的检测方法,该检测方法是基于协议和ALK,ALK蛋白的高成本需要长时间的捕鱼污染模式分析过度表达提供了一种通过有效分析模型的方法,可以用于检测ALK基因重排,从而有效地快速,准确地确定配药对象是否主要ALK破坏者,扩展治疗(治疗)的范围,可以利用分子靶标起作用。

著录项

  • 公开/公告号KR20120056660A

    专利类型

  • 公开/公告日2012-06-04

    原文格式PDF

  • 申请/专利权人 SEOUL NATIONAL UNIVERSITY BUNDANG HOSPITAL;

    申请/专利号KR20100118308

  • 发明设计人 PAIK JIN HO;CHUNG JIN HAENG;

    申请日2010-11-25

  • 分类号G01N33/574;G01N33/532;C12N15/12;C12Q1/68;

  • 国家 KR

  • 入库时间 2022-08-21 17:09:54

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