DIAGNOSTIC KIT FOR LUNG DUE TO HYPEROXIDATION EXPOSURE AND A MANUFACTURING METHOD OF A LUNG DAMAGED MOUSE MODEL CAPABLE OF USING LUNG DAMAGED ANIMAL MODEL DUE TO HYPEROXIDATION EXPOSURE AND TAZ MARKER

摘要

PURPOSE: A diagnostic kit for lung due to hyperoxidation exposure and a manufacturing method of a lung damaged mouse model are provided to screen treatment candidates.;CONSTITUTION: A manufacturing method of a lung damaged mouse model comprises the following steps: manufacturing TAZ gene knockout cassette; transfecting the TAZ gene knockout cassette in the embryonic stem cell; obtaining a chimera mouse by injecting into an embryonic stem cell of blastocele of the cannonade embryo bud; obtaining a heterozygote mouse having TAZ+/- hereditary characters from the chimera mouse; interbreeding the heterozygote mouse; and obtaining the homozygote mouse having TAZ-/- hereditary character.;COPYRIGHT KIPO 2012