METHOD FOR INPUT AND OUTPUT DATA FOR NONLINEAR MIXED EFFECTS MODELING OF POPULATION PHARMACOKINETICS AND PHARMACODYNAMICS

摘要

PURPOSE: An information input and output method for the non-linear mixture model of population pharmacokinetics-pharmacodynamics is provided to analyze results for the non-linear model and to arrange materials for the non-linear model. CONSTITUTION: Materials for the non-linear mixture model of population pharmacokinetics-pharmacodynamics are inputted in a spread sheet(S100). The detection result of the inputted materials are outputted(S111). The non-linear mixture model is constructed by the inputted materials(S120). The construction result of the non-linear mixture model is outputted using a result table(S141). [Reference numerals] (AA) Start; (BB) End; (CC) Yes; (DD) No; (S100) Content preparing and input; (S110) Content verification?; (S111) Verification result output; (S112) Is modification necessary?; (S120) A non-linear combination effect model is constructed; (S130) Execution result file output; (S140) Result table output?; (S141) Result table output?; (S150) Estimated value and standard error output?; (S151) Estimated value and standard error output?; (S160) Plot output?; (S161) Plot input value selection; (S162) Plot output; (S170) Model tree output?; (S171) Model tree output; (S180) Verification?; (S181) Many time modeling repetition; (S182) Verification result output