COMPOSITION FOR LOWERING BLOOD SUGAR AND CHOLESTEROL COMPRISING HIGH MOLECULAR WEIGHT SILK FIBROIN AND ITS PREPARATION METHOD

摘要

PURPOSE: A method for preparing silk fibroin of high molecular weight is provided to reduce blood glucose and cholesterol. CONSTITUTION: A composition for reducing blood glucose or cholersterol contains silk fibroin of high molecular weight as an active ingredient. The silk fibroin is 10%(w/w) silk formic acid solution with 70-350 of viscosity. The composition further contains sericin as an active ingredient. A health food for relieving or preventing diabetes, obesity, or hyperlipidemia contains the composition. A method for preparing the silk protein comprises: a step of refining silk cocoon and refining in distilled water at 90-100C for 1-3 hours; a step of washing the refined silk cocoon using distilled water at 60-80C; a step of dissolving the washed silk cocoon with a mixture solvent of LiBr solution or CaCl_2/water/ethanol; a step of removing salt by a cut-off tube; and a step of freeze-drying the silk protein solution.