Method for the production of amino crotonyl compounds? ??? 4-3-???-4-?????????-6-4-N,N-??????-1-??-2-??-1-????-7-S-?????????-3-???????? ?? ??????? ??? ? ?????? ???? ?? ?, ?? 4-3-???-4-?????????-6-4-N,N-??????-1-??-2-??-1-????-7-S-?????????-3-???-???? ??????? ??? ???? ? 4-3-???-4-?????????-6-4-N,N-??????-1-??-2-??-1-????

摘要

An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.