SOLID PHARMACEUTICAL COMPOSITION (OPTIONS), METHOD FOR PRODUCING SOLID PHARMACEUTICAL COMPOSITION (OPTIONS), TABLET (OPTIONS) AND METHOD FOR PRODUCING AMPHOR PARTICLES

摘要

1. A solid pharmaceutical composition for oral administration comprising about 0.01 ÷ 20 wt.% IN-105, about 10 ÷ 60 wt.% Saturated or unsaturated C4-C12 fatty acids, their esters or salts, and at least three pharmaceutically acceptable excipients selected from the group comprising at least 10 wt.% disintegrant, 10 wt.% diluent, 0.5 wt.% lubricant, optionally including binders, plasticizers, penetration enhancers, or solubilizers. ! 2. The composition according to claim 1, in which the fatty acid is capric acid and / or lauric acid or their salts. ! 3. The composition according to claim 1, in which the fatty acid is a sodium caprate. ! 4. The composition according to claim 1, in which the binder component is selected from the group comprising polyvinylpyrrolidone, carboxymethyl cellulose, methyl cellulose, starch, gelatin, sugars, natural or synthetic gums, or combinations thereof. ! 5. The composition according to claim 4, in which the binder component is polyvinylpyrrolidone. ! 6. The composition according to claim 1, in which the diluents are selected from the group comprising calcium salts, cellulose or cellulose derivatives, palatinose, organic acids, sugar and sugar alcohols, pectic acid salts and combinations thereof. ! 7. The composition according to claim 6, in which the diluent is mannitol. ! 8. The composition according to claim 1, in which the baking powder is selected from the group comprising cross-linked polyvinylpyrrolidone, carboxymethyl cellulose, methyl cellulose, cation exchange resins, alginic acid, guar gum, and combinations thereof. ! 9. The composition according to claim 1, in which the lubricant is selected from the group including