METHOD FOR OBTAINING SODIUM CARBOXYMETHYL CELLULOSE AND GOSSYPOL COPOLYMER AND ITS APPLICATION IN COMPLEX THERAPY OF PATIENTS WITH AUTISTIC DISORDERS AND COGNITIVE DISORDERS

摘要

1. A method of obtaining a copolymer of sodium carboxymethyl cellulose with a degree of substitution of 0.35-0.80 and gossypol of the formula (I):! ! where a: b: c = 1: (3-6) :( 5-7),! n = 40-50; ! molecular weight 120000-130000, including the interaction of an aqueous solution of sodium carboxymethyl cellulose with a degree of substitution of 0.35-0.80 with an aqueous solution of iodic acid or sodium periodate, followed by isolation of the carboxymethyl cellulose dialdehyde, treatment of the resulting product with gossypol or gossypolacetic acid, then an aqueous alkali solution and isolation of the target product by precipitation with an organic solvent, characterized in that the interaction of an aqueous solution of sodium carboxymethyl cellulose with a degree of substitution of 0.35-0.80 with an aqueous solution of iodic acid or sodium periodate is carried out while passing through the reaction solution of carbon dioxide until the pH of the solution is 3.0-4.5. ! 2. The use of a copolymer of sodium carboxymethyl cellulose with a degree of substitution of 0.35-0.80 and gossypol of the formula (I)! ! where a: b: c = 1: (3-6) :( 5-7),! n = 40-50; ! molecular weight of 120,000-130000; ! in the complex treatment of patients with autistic disorders and cognitive impairment. ! 3. The use according to claim 2, where the copolymer of sodium carboxymethyl cellulose with a degree of substitution of 0.35-0.80 and gossypol of formula (I) is obtained by the method according to claim 1. ! 4. The use according to claim 2 or 3, where the copolymer of sodium carboxymethyl cellulose with a degree of substitution of 0.35-0.80 and gossypol of the formula (1) is used in combination with a means for treating cognitive disorders selected from one or more antipsychotics, antidepressants, anticonvulsants or combinations thereof. ! 5. The pharmaceutical composition intended for use in the treatment of pa