首页> 外国专利> New multicomponent crystals of 2- 2-amino-6- (4-fluoro-benzylamino) -pyridin-3-yl -carbamic acid ethyl ester and 2- 2 - (2,6-dichlorophenyl) -amino -phenyl -acetic acid

New multicomponent crystals of 2- 2-amino-6- (4-fluoro-benzylamino) -pyridin-3-yl -carbamic acid ethyl ester and 2- 2 - (2,6-dichlorophenyl) -amino -phenyl -acetic acid

机译:[2- [2-氨基-6-(4-氟-苄氨基)-吡啶-3-基]-氨基甲酸乙酯和2- [2-[(2,6-二氯苯基)-氨基]的新的多组分晶体-苯基]-乙酸

摘要

The present invention relates to novel multicomponent crystals, their preparation and their use for the treatment of pain, in particular unclear genesis, by a simultaneous action on pain caused by muscle tension or degenerative joint disease, as well as those based on inflammatory processes. The novel multicomponent crystals are composed of the active ingredients ([2-amino-6- (4-fluoro-benzylamino) -pyridin-3-yl] -carbamic acid ethyl ester (flupirtine) and 2- [2 - [(2,6-dichlorophenyl) - amino] -phenyl] -acetic acid (diclofenac) and can be prepared by dissolving the two components in a molar ratio of 1.0: 0.9 to 1.0: 1.1 in an inert organic solvent and then crystallizing out the complex compound ,
机译:本发明涉及新颖的多组分晶体,它们的制备及其用于通过同时作用于由肌肉紧张或退化性关节疾病引起的疼痛以及基于炎症过程的疼痛来治疗疼痛,特别是不清楚的起源。新型多组分晶体由有效成分([2-氨基-6-(4-氟-苄基氨基)-吡啶-3-基]-氨基甲酸乙酯(氟吡汀)和2- [2-[(2, (6-二氯苯基)-氨基]-苯基]-乙酸(双氯芬酸),可以通过将两种组分以1.0:0.9至1.0:1.1的摩尔比溶解在惰性有机溶剂中,然后使配合物结晶而制备,

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