Preparing salt of O-acetylsalicylic acid of basic amino acid, by contacting, in reactor, aqueous solution of basic amino acid and solution of O-acetylsalicylic acid dissolved in solvent, and introducing part of basic amino acid in reactor

摘要

Preparing a salt of O-acetylsalicylic acid of basic amino acid, comprises continuously contacting, in a reactor (4), an aqueous solution of basic amino acid and a solution of O-acetylsalicylic acid dissolved in a solvent, and introducing a part of basic amino acid in the reactor, where: a quantity of the basic amino acid is relative to a stoichiometry ratio; and a weight concentration of the solutions is less than a saturation and higher than 5 wt.% of O-acetylsalicylic acid and 20 wt.% of basic amino acid. Preparing a salt of O-acetylsalicylic acid of basic amino acid, comprises continuously contacting, in a reactor (4), an aqueous solution of basic amino acid and a solution of O-acetylsalicylic acid dissolved in a solvent, and introducing a part of basic amino acid in the reactor, where: a quantity of the basic amino acid is relative to a stoichiometry ratio; a weight concentration of the solutions is less than a saturation and higher than 5 wt.% of O-acetylsalicylic acid and 20 wt.% of basic amino acid; the reaction is carried out in suspension under an agitation effect with an expenditure of energy of 0.5-2 W/l of reactional medium; a temperature of the reactional medium in the reactor is constant and is 2-25[deg] C; a reactor volume and supply flow values are such that the reaction solutions are maintained in the reactor for 15-60 minutes; an output flow from the reactor is directly supplied to a device (12), which separates the liquid phase and solid phase from output flow; and the solid phase formed in the reactor is dried for obtaining the salt in the form of powder.