DUAL ACTION, INHALED FORMULATIONS PROVIDING BOTH IMMEDIATE AND SUSTAINED RELEASE PROFILE

摘要

PROBLEM TO BE SOLVED: To provide dual action inhaled formulations for immediate and sustained release of a drug, such as anti-infectives delivered by inhalation for the treatment of cystic fibrosis.SOLUTION: There is provided an aerosolized composition of particles, comprising: a free, unencapsulated first pharmaceutically active drug; a pharmaceutically acceptable excipient; and a liposome-encapsulated second pharmaceutically active drug. The aerosolized composition is formulated for aerosolized delivery, wherein the first and the second pharmaceutically active drug are each an anti-infective and the particles of the aerosol have a diameter in a range from about 2 microns to about 4 microns, and the anti-infective is ciprofloxacin.