In vivo drug sustained release carrier material comprising hydrogel crosslinked with ionizing radiation and method for producing the same

摘要

Two types of drug release profiles, linear release and two-stage release, can be controlled, and the drug adsorption capacity is superior to chemically cross-linked biodegradable polymer water-soluble substances. In addition, a carrier material for sustained release of an in vivo drug derived from a biodegradable polymer water-soluble substance and a method for producing the same are provided. A biomaterial sustained release carrier material comprising a hydrogel obtained by crosslinking a biodegradable polymer water-soluble substance such as gelatin in an inert gas atmosphere such as nitrogen with ionizing radiation, the hydrogel having a temperature of 40 ° C. It has an uncrosslinked portion and a crosslinked portion that are soluble in water in a mass ratio of 95: 5 to 5:95, preferably 95: 5 to 55:45, and the carrier material carries a drug. In vivo drug sustained release carrier material that exhibits two-stage release properties after being embedded in the living body, or in vivo drug sustained release carrier material that is substantially free of uncrosslinked portions obtained by washing the hydrogel with water And methods for producing these carrier materials.