Gene Expression Profiling in Primary Ovarian Serous Papiliary Tumors and Normal Ovarian Epithelum

摘要

Provided herein are methods for detecting ovarian serous papillary carcinoma in an individual. A tumor sample from the individual is examined for gene product expression levels of a group of genes consisting of transforming growth factor beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family member I (ARHI), thrombospondin 2, and disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2) Gene products which are down-regulated compared to those in a control individual indicate the presence of ovarian serous papillary carcinoma