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Magnetic Resonance Methodology for Imaging of Exchange-Relayed Intramolecular Nuclear Overhauser Enhancement Effects in Mobile Solutes
Magnetic Resonance Methodology for Imaging of Exchange-Relayed Intramolecular Nuclear Overhauser Enhancement Effects in Mobile Solutes
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机译:磁共振方法学用于流动溶质中交换中继分子内核超负荷分子增强效应的成像
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摘要
An embodiment in accordance with the present invention provides a method for imaging exchange-relayed intramolecular Nuclear Overhauser Enhancement (NOE) effects with Magnetic Resonance (MR) in mobile solutes. In the method, non-exchangeable protons or other magnetic nuclei with resonances of a finite linewidth in the NMR proton spectrum within a species or subject can be labeled magnetically using radiofrequency. Intramolecular NOE effects can then transfer the label between the non-exchangeable nuclei and non-exchangeable and exchangeable protons in the same molecule during a magnetic steady state. The water signal is monitored to observe a reduction in the water signal due to the transfer of NOE labels to the water signal in a manner relayed through the exchangeable protons. Analysis can also be performed to produce an image or spectrum of the subject.
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